Uric Acid and Erectile Dysfunction

Elevated levels of uric acid are associated with several chronic health conditions including diabetes, obesity, dyslipidemia, gout, and high blood pressure. Uric acid is produced when the body breaks down purine, a naturally occurring chemical in the body that is also found in certain foods.

Among other effects, increased uric acid decreases nitric oxide (NO) function. NO allows blood vessels to relax and help keep blood pressure down. This relationship is how elevated uric acid results in the risk of high blood pressure, cardiovascular disease, and type 2 diabetes. When blood vessels constrict, not only does blood pressure increase, but blood flow to vital organs decreases.

According to a study published in the Journal of Sexual Medicine, there is a relationship between elevated uric acid level and erectile dysfunction (ED) as a result of reduced NO function. (Widely prescribed ED drugs work to increase NO.) The 2014 study examined 312 men with coronary artery disease and found that 48% had erectile dysfunction and elevated uric acid. Researchers concluded that elevated uric acid is a predictor of ED in men at risk for coronary artery disease.

In addition, researchers found a 31% increase in the risk of ED for every 1 mg/dl increase in uric acid across all patients, including those without coronary artery disease.

Uric acid may be controlled by diet. Many diets have been developed to help gout sufferers reduce their uric acid. The Mayo Clinic’s gout diet recommendations include:

• Lose weight, as weight loss contributes to lower uric acid levels even without restricting one’s diet.
• Eat more complex carbohydrates like those found in fruits (especially cherries), vegetables, and whole grains.
• Drink plenty of water.
• Eat lean meat and chicken, low-fat diary, and lentils for protein.
• Avoid organ meats like liver and kidneys.
• Limit or eliminate red meats like beef, lamb, and pork.
• Avoid seafood that is higher in purines such as anchovies, shellfish, sardines, and tuna.
• Avoid beer and distilled alcohol, although moderate wine consumption may be tolerated.
• Limit or eliminate sugar-sweetened foods and beverages.
• Consider a vitamin C supplement after consultation with your health practitioner.
• Drink coffee in moderation, unless otherwise directed by your health practitioner.